After graduating in 1994, Clement went on to attend the University of Miami, a college football powerhouse who had been hurt by NCAA sanctions. With the Hurricanes, Clement would split the starting quarterback role in 1995 with Ryan Collins. Clement replaced Collins in the third game of the 1995 season against Virginia Tech when Collins was sidelined with an injury. Clement started the remaining 8 games, losing his first start to Florida State but finishing the season with 7 wins in a row. After a slow start in 1995, going 1-3 before finishing the season at 8-3, Miami would still have participated in a post-season bowl because of its strong finish. Miami, however, was ineligible for bowl game participation due to NCAA sanctions. This was Butch Davis’ first year as Head Coach of the Hurricanes.
Clement took over the starting role full time in 1996, leading the Big East in pass efficiency with a 147.1 rating. Clement was a leading candidate for the Davey O’Brien National Quarterback Award in 1996 and was also an All-Big East Conference selection. He led the Hurricanes to the Big East title shared with Virginia Tech and Syracuse (all finished 6-1 in conference play) with an impressive performance in the final game of the season at Syracuse. Clement threw for three touchdowns to help Miami defeat the Donovan McNabb led Orangemen 38-31, earning Big East Player of the Week honors and giving Miami a share of the Big East conference crown. Miami finished the 1996 season 9-3, with a win over Virginia in the Carquest Bowl and ranked 14th in both the AP and coaches polls. 1997 proved to be an extremely difficult year for Clement and the Hurricanes. Miami, beset by the scholarship reductions due to NCAA violations under the Dennis Erickson tenure, and forced to play several true freshmen as starters in key positions, fell to a 5-6 record, their first losing record since 1979.
Clement led the Miami Hurricanes in 30 regular season games as the starting quarterback over three seasons, and led his team to a win in the 1996 Carquest Bowl in the only post-season game he started. He received the Walter Kichefski Football Award, selected by his coaches as the Miami player that most represents the characteristics Kichefski lived by: respect for fellow man, loyalty, dedication, sacrifice, motivation and inspiration. Ryan Clement finished his career at Miami among the all-time statistical leaders in the following categories: Career Pass Completion Percentage:(Minimum 250 Attempts) – (443 of 747) – 59.3% (4th All-Time), Career Pass Completions: 443 (4th All-Time), Career Pass Attempts: 747 (4th All-Time), Career Passing Yardage: 6,004 (5th All-Time), Career Total Offense: 5,659 (5th All-Time), Career Touchdown Passes: 43 (6th All-Time). He also owns two individual season marks for Pass Completion Percentage for the 1996 season of 60.3% (164 of 272) (6th All-Time) and for the 1995 season of 59.2% (199 of 201) (10th All-Time).